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KMID : 0380019940090020224
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Korean Journal of Biotechnology and Bioengineering
1994 Volume.9 No. 2 p.224 ~ p.228
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Production of Antifungal Lipopeptide Iturin Bacillus subtilis
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손광현/Son, Kwang Hyun
이항우/김성욱/복성해/김정희/Lee, Hang Woo/Kim, Sung Uk/Bok, Sung-Hae/Kim, Jung-Hoe
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Abstract
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Iturin, an antifungal lipopeptide, fermentation by Bacillus subtilis was investigated focusing on the effects of nutrients, aeration and specific cell growth rate on iturin production. Cell growth and product formation were not affected by different kinds of carbon sources such as sucrose, glucose and fructose. Soytone concentration above 20g L did not influence iturin production. Diauxic growth pattern appeared when only soytone was used as a sole nitrogen sourse probably due to the shortage of amino aside and or peptides in soytone which could be favorably assimilated by the cells. The composition of three major components in iturin was not changed significantly by the variation of dissolved oxygen concentration of the culture broth, but changed substantially by the change of specific growth rate of the cells.
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KEYWORD
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